Metabolic and Cardiovascular biomarkers as well as Visceral Adipose Tissue (VAT) are key indicators central to the modern physician's assessment of a patient's physical well-being. Modern science has turned to nature, traditional medicine and lifestyle choices such as the Mediterranean diet to explain why they have a profound impact on health. In doing so we have discovered phytonutrients that positively modulate and improve human health and that are supported by both traditional use and practice as well as now, modern science. Bergamot and olive have long been revered for both culinary, medicinal and health-promoting reasons, exemplifying the famous quote “let food be thy medicine”. Today we can harness their tremendous potential to act as therapeutic agents, targeting and modulating major biomarkers of health.